Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction
نویسندگان
چکیده
منابع مشابه
Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction
The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to chronic inflammation and disease. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms. The cytoplasmic tail (ct) of RAGE is essential for RAGE ligand-mediated signal transduction and...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep22450